The catheter approach became the standard procedure after the MR CLEAN study led by neurologist Prof. Then the blood clot is removed through the catheter. The catheter is advanced into the occluded blood vessel in the brain. In catheter treatment, a patient with an acute ischemic stroke has a thin catheter inserted into an artery in the groin. The researchers report their findings in the scientific journal The Lancet. In total, the researchers included 628 patients in the study before it was terminated early because of the findings. In addition, there was no evidence that patients recovered better when given antithrombotic drugs. Intracerebral hemorrhage occurred in 14 percent of patients in the acetylsalicylic acid group and 13 percent in the heparin group, versus 7 percent of patients in the control group. Patients who were given intravenous acetylsalicylic acid or heparin had about twice the incidence of serious intracerebral hemorrhage compared to patients who did not receive antithrombotic drugs. Until now, however, it was unknown whether the potential benefits of these drugs outweighed the increased risk of a intracerebral hemorrhage. Additional antithrombotic therapy should ensure that the smaller blood vessels also open up. In this treatment, the blood clot is removed from the brain with a catheter via the femoral artery in the groin.
In the MR CLEAN-MED trial, a team led by the Erasmus MC investigated the effectiveness and safety of using antithrombotic drugs acetylsalicylic acid (aspirin) and heparin during the catheter treatment of stroke.
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